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Source: STEP 1 trial data (Wilding et al., NEJM 2021) Tip: If side effects are severe at a new dose, your prescriber may hold the current level for an extra 4 weeks or drop back to the previous dose temporarily

Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass

Jon Wertheim: This drug that we're seeing right here helped save the life of Marie

Moreover, the pharmacokinetics of injected GLP-1 RAs can be a limitation, necessitating frequent dosing schedules that may deter long-term use

Topiramate does not affect cardiovascular parameters but requires attention to hydration and kidney stone prevention